منابع مشابه
Changes of serum thymidine kinase in children with acute leukemia.
BACKGROUND Thymidine kinase (TK) is involved in nucleic acid synthesis and is therefore considered to be an important proliferation tumor marker. Our main goal was to determine the significance of elevated TK levels as a relapse marker during follow-up with child patients suffering from acute leukemia. PATIENTS AND METHODS TK serum levels in 38 children with acute leukemia (34 lymphoblastic, ...
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In patients with acute myeloblastic leukaemia the mean serum ferritin concentration showed a twenty-five-fold increase compared with normal people, and in children with acute lymphoblastic leukaemia (A.L.L.) there was a thirteen-fold increase. The high concentration of circulating ferritin seemed to be related to increased synthesis by leukaemic cells. The return of serum concentrations to norm...
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Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...
متن کاملHuman Thymidine Kinase
Cytosolic thymidine kinase (EC 2.7.1.21) has been purified 5200-fold to apparent homogeneity from normal human placenta. The purification includes sequential affinity chromatography on blue-Sepharose and a thymidine column. The molecular weight of the enzyme determined by gel filtration and sucrose density ultracentrifugation is 92,000. The subunit molecular weight is 44,000, suggesting that t...
متن کاملDacryocystitis in Acute Leukaemia.
LEUKAEMIC infiltration of the lacrimal sac is rare (Duke-Elder, 1952) and dacryocystitis due to leukaemic involvement of the sac has seldom been reported (Stokes, 1938; Busina, 1950). The number of cases recorded is increased when the reports of Sulzer and Duclos (1906), Pascheff (1927), and Weve (1928) are considered, but these authors described lymphomata of the sac without the typical blood ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1984
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1984.82